Scientific References
| Product | Section | Claim | Evidence #1 | Evidence #2 | Evidence #3 | ||
| Wegovy | Product Tile | FDA-approved semaglutide weight loss injectable | https://www.wegovy.com/ | ||||
| Wegovy | Product Tile | Accelerates weight loss & helps keep weight off | https://www.wegovy.com/ | ||||
| Acarbose | Product Tile | Supports healthier long-term weight | https://www.frontiersin.org/articles/10.3389/fendo.2020.00288/full&sa=D&source=docs&ust=1663615935017059&usg=AOvVaw2l24UQACry7smk9p1J3tJr | ||||
| LDN | Product Tile | Encourages weight loss | Naltrexone HCI/bupropion HCI for chronic weight management in obese adults: patient selection and perspectives | Naltrexone effects on insulin sensitivity and insulin secretion in hyperandrogenic women | |||
| Orlistat | Product Tile | FDA approved for weight loss ( | Orlistat, a New Lipase Inhibitor for the Management of Obesity | Link | |||
| Orlistat | Product Tile | free fatty acids are not absorbed.[ | StatPearls (NIH) | Link | Link | ||
| LDN | Product Tile | May support appetite reduction | Effects of naltrexone on food intake and changes in subjective appetite during eating: evidence for opioid involvement in the appetizer effect | Link | |||
| Acarbose | Product Tile | Safe and effective for blocking starch and sucrose (carbs) | Safety and efficacy of acarbose in the treatment of diabetes in Chinese patients | Link | |||
| B6 | Product Tile | B6 may help with nausea | Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study | Link | |||
| B12 | Product Tile | Studies suggest lower b12 levels correlate with higher obesity levels | https://pubmed.ncbi.nlm.nih.gov/23892832/ | ||||
| B12 | Header | Increase energy levels & reap multiple health benefits with a naturally-occurring form of vitamin B—all at a fraction of the cost of infusions. | https://journals.sagepub.com/doi/10.1177/0004563212473279 | https://pubmed.ncbi.nlm.nih.gov/23592803/ | |||
| B12 | Benefits | Effective in fighting fatigue & enhancing natural energy | https://youtu.be/KeXOv8m2HF8 |
1. Bruins Slot, W., Merkus, F. W., Deventer, S. J. H. V., & Tytgat, G. N. (1997). Normalization of plasma vitamin B12 concentration by intranasal hydroxocobalamin in vitamin B12-deficient patients. Gastroenterology, 113, 430-433. 2. Daily Intake. (2017). Canadian Food Inspection Agency. Retrieved 30 October 2017, from http://www.inspection.gc.ca.libaccess... 3. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B b6 s, folate, vitamin B b12 s, pantothenic acid, biotin, and choline. (1998) (pp. 306-356). Washington, D.C. 4. Ermens, A., Vlasveld, L., & Lindemans, J. (2003). Significance of elevated cobalamin (vitamin B12) levels in blood. Clinical Biochemistry,36(8), 585-590. doi:10.1016/j.clinbiochem.2003.08.004 5. Ganeson, S., Thanawala, N., & Hussain, N. (2013). Vitamin B12 deficiency: a treatable cause of developmental delay in infancy. J Paediatric Child Health, 49(4): E348-349. doi: 10.1111/jpc.12158 6. Gropper SS, Smith JL, Groff JL. Advanced Nutrition and Human Metabolism: Fourth Edition. Boston, MA: Wadsworth (2004). 7. Hashim, O. H., & Adnan, N. A. (1994). Coenzyme, cofactor and prosthetic group — Ambiguous biochemical jargon. Biochemical Education,22(2), 93-94. doi:10.1016/0307-4412(94)90088-4 8. Hvas, A., & Nexo, E. (2006). Diagnosis and treatment of vitamin B12 deficiency. An update. Haematologica, 91(11), 1506-1512. 9. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. (1998). Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. National Academies Press (US). 10. Kwong, J. C., Carr, D., Dhalla, I. A., Tom-Kun, D., & Upshur, R. E. (2005). Oral vitamin B 12 therapy in the primary care setting: a qualitative and quantitative study of patient perspectives. BMC family practice, 6(1), 8. 11. . Langan, R. C., & Goodbred, A. J. (2017). Vitamin B 12 Deficiency: Recognition and Management. American Family Physician, 96(6). 12.. Miller, A., Korem, M., Almog, R., & Galboiz, Y. (2005). Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. Journal of the Neurological Sciences,233(1-2), 93-97. doi:10.1016/j.jns.2005.03.009 13. Møllehave, L. T., Skaaby, T., Simonsen, K. S., Thuesen, B. H., Mortensen, E. L., Sandholt, C. H., ... & Linneberg, A. (2017). Association studies of genetic scores of serum vitamin B12 and folate levels with symptoms of depression and anxiety in two danish population studies. European Journal of Clinical Nutrition, 71(9), 1054-1060. 14. National Heart, Lung, and Blood Institute (2011). What are the signs and symptoms of pernicious anemia? Retrieved from https://www.nhlbi.nih.gov/health/heal... 15. Niculescu, M., & Zeisel, S. (2002). Diet, Methyl Donors and DNA Methylation: Interactions between Dietary Folate, Methionine and Choline. The Journal of Nutrition,132, 2333-2335. 16. Oh, R., & Brown, D. (2003). Vitamin B12 Deficiency. American Family Physician, 67(5), 979-986. Retrieved from http://www.aafp.org.libaccess.lib.mcm... 17. Osimani, A., Berger, A., Friedman, J., Porat-Katz, B. S., & Abarbanel, J. M. (2005). Neuropsychology of vitamin B₁₂ deficiency in elderly dementia patients and control subjects. Journal of geriatric psychiatry and neurology, 18(1), 33-38. 18. Vogiatzoglou, A., Smith, A. D., Nurk, E., Berstad, P., Drevon, C. A., Ueland, P. M., ... & Refsum, H. (2009). Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study. The American journal of clinical nutrition, 89(4), 1078-1087. 19. Whitney, E., Rolfes, S., Hammond, G., & Piche, L. (2011). Understanding Nutrition (1st ed., pp. 332-334). Toronto: Nelson Education Ltd. |
|||
| B12 | Benefits | Encourages higher quality sleep | See video above + all sources cited to support these claims. B12 is a well-studied and well-understood vitamin with an incredible amount of background information/safety/health data to support it. | ||||
| B12 | Benefits | Helps regulate mood | See video above + all sources cited to support these claims. B12 is a well-studied and well-understood vitamin with an incredible amount of background information/safety/health data to support it. | ||||
| B12 | Benefits | Promotes healthy skin & nails | See video above + all sources cited to support these claims. B12 is a well-studied and well-understood vitamin with an incredible amount of background information/safety/health data to support it. | ||||
| B12 | Benefits | Boosts metabolic function | See video above + all sources cited to support these claims. B12 is a well-studied and well-understood vitamin with an incredible amount of background information/safety/health data to support it. | ||||
| B12 | Benefits | Shown to help prevent cardiovascular disease | See video above + all sources cited to support these claims. B12 is a well-studied and well-understood vitamin with an incredible amount of background information/safety/health data to support it. | ||||
| B12 | Benefits | Strengthens bone density & overall skeletal health | See video above + all sources cited to support these claims. B12 is a well-studied and well-understood vitamin with an incredible amount of background information/safety/health data to support it. | ||||
| B12 | Benefits | Background & History B12 is an essential vitamin the body needs but cannot produce First accounts of B12 supplementation date back to 1849 Up to 15% of Americans are deficient in B12 Nutrient deficiencies & gut-related health issues increase likelihood of B12 deficiency Contains methylcobalamin B12, a naturally-occurring form (unlike cyanocobalamin) vital to central nervous system function Intramuscular injection delivers B12 directly into the bloodstream, unlike other methods (e.g. pills) |
https://journals.sagepub.com/doi/10.1177/0004563212473279 | ||||
| B12+MIC | Header | Enhance your healthy lifestyle with all the benefits of B12 + a unique blend of ingredients to support your weight loss journey. |
Dietary Methionine Restriction Increases Fat Oxidation in Obese Adults with Metabolic Syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085194/ | Effects of three treatment modalities (diet, myoinositol or myoinositol associated with D-chiro-inositol) on clinical and body composition outcomes in women with polycystic ovary syndrome https://www.europeanreview.org/article/17278 | Higher Dietary Choline and Betaine Intakes Are Associated with Better Body Composition in the Adult Population of Newfoundland, Canada https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863971 | ||
| B12+MIC | Benefits | Supports fat removal in the liver & neutralizes bodily toxins | Dietary Methionine Restriction Increases Fat Oxidation in Obese Adults with Metabolic Syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085194/ | ||||
| B12+MIC | Benefits | B12 boosts energy & discourages onset of general fatigue | Effects of three treatment modalities (diet, myoinositol or myoinositol associated with D-chiro-inositol) on clinical and body composition outcomes in women with polycystic ovary syndrome https://www.europeanreview.org/article/17278 | Vitamin B12 in Health and Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257642/ |
|||
| B12+MIC | Benefits | Inositol & a healthy diet can help initiate modest weight loss | Effects of three treatment modalities (diet, myoinositol or myoinositol associated with D-chiro-inositol) on clinical and body composition outcomes in women with polycystic ovary syndrome https://www.europeanreview.org/article/17278 | ||||
| B12+MIC | Benefits | Choline shown to help build lean muscle mass | https://www.sciendo.com/article/10.2478/hukin-2014-0009 | ||||
| B12+MIC | Benefits | Complements a healthy lifestyle to break through plateaus | Effects of three treatment modalities (diet, myoinositol or myoinositol associated with D-chiro-inositol) on clinical and body composition outcomes in women with polycystic ovary syndrome https://www.europeanreview.org/article/17278 | ||||
| B12+MIC | Benefits | Gentle & effective for sensitive stomachs | Bypasses the stomach by a direct IM injection - no citation needed? | ||||
| Wegovy | Header | FDA-approved semaglutide injection proven to help you lose weight & keep it off. | https://www.wegovy.com/ | ||||
| Wegovy | Benefits | "Wegovy™ works by mimicking a hormone that targets areas of the brain involved in regulating appetite and food intake. This can help you eat less, which can lead to weight loss." | In adults with obesity, once-weekly s.c. semaglutide 2.4 mg suppressed appetite, improved control of eating, and reduced food cravings, ad libitum energy intake and body weight versus placebo. |
https://www.wegovy.com/ | |||
| Wegovy | Benefits | Helps to regulate appetite & caloric intake | https://www.wegovy.com/FAQs/frequently-asked-questions.html |
The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity | |||
| Wegovy | Benefits | Ideal for adults with BMI >27 (more than 20lbs to lose) | https://www.wegovy.com/ | ||||
| Wegovy | Benefits | Improves blood pressure & cholesterol levels | https://www.wegovy.com/about-wegovy/weight-loss-with-wegovy.html | ||||
| Wegovy | Benefits | Lowers blood sugar levels | https://www.wegovy.com/about-wegovy/weight-loss-with-wegovy.html | ||||
| Wegovy | Benefits | Use with reduced-calorie meal plan & exercise for best results | https://www.wegovy.com/FAQs/frequently-asked-questions.html "Wegovy™ should be used with a reduced-calorie meal plan and increased physical activity." |
||||
| Wegovy | Background & History | The active ingredient in Wegovy™ is semaglutide | https://www.wegovy.com/about-wegovy/how-does-wegovy-work.html | ||||
| Wegovy | Background & History | FDA-approved for weight loss | https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-chronic-weight-management-first-2014 | ||||
| Wegovy | Background & History | Mimics glucagon-like peptide (GLP-1), a hormone that regulates appetite & food intake | https://www.wegovy.com/about-wegovy/how-does-wegovy-work.html | ||||
| Wegovy | Background & History | Administered once weekly with convenient injectable pen | https://www.wegovy.com/about-wegovy/how-to-use-the-wegovy-pen.html | ||||
| Wegovy | Background & History | Dosages titrates up over several months for maximum results | https://www.wegovy.com/about-wegovy/dosing-schedule.html | ||||
| Wegovy | Background & History | In a 68-week study, adults lost ~35lbs or 15% body weight | https://www.wegovy.com/about-wegovy/weight-loss-with-wegovy.html | ||||
| Wegovy | Background & History | Weight control is a key factor in general longevity | https://pubmed.ncbi.nlm.nih.gov/12513041/ | ||||
| Wegovy | Background & History | Lowering your BMI can help reduce risk of age-related and/or inflammatory diseases | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240791/#:~:text=Serum%20concentrations%20of%20a%20number,disease%20(4%2D6). | ||||
| Wegovy | Safety | Weight loss with semaglutide was accompanied by greater improvements than placebo with respect to cardiometabolic risk factors, including reductions in waist circumference, blood pressure, glycated hemoglobin levels, and lipid levels; a greater decrease from baseline in C-reactive protein, a marker of inflammation |
MFG LABEL - includes black-box warning | https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/215256s000lbl.pdf | |||
| Wegovy | Benefits | Resulted in material improvement in cardio and inflammation metrics | |||||
| Semaglutide | Background & History | The active ingredient in Wegovy™ is semaglutide | https://www.wegovy.com/about-wegovy/how-does-wegovy-work.html | ||||
| Semaglutide | Semaglutide Benefits | FDA-approved for weight loss | https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-chronic-weight-management-first-2014 | ||||
| Semaglutide | Semaglutide Benefits | Helps to regulate appetite & caloric intake | https://www.wegovy.com/FAQs/frequently-asked-questions.html |
||||
| Semaglutide | Semaglutide Benefits | Use with reduced-calorie meal plan & exercise for best results | https://www.wegovy.com/FAQs/frequently-asked-questions.html "Wegovy™ should be used with a reduced-calorie meal plan and increased physical activity." |
||||
| Semaglutide | Semaglutide Benefits | In a 68-week study, adults lost ~35lbs or 15% body weight | https://www.wegovy.com/about-wegovy/weight-loss-with-wegovy.html | ||||
| Semaglutide | Safety | Weight loss with semaglutide was accompanied by greater improvements than placebo with respect to cardiometabolic risk factors, including reductions in waist circumference, blood pressure, glycated hemoglobin levels, and lipid levels; a greater decrease from baseline in C-reactive protein, a marker of inflammation. |
MFG LABEL - includes black-box warning | https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/215256s000lbl.pdf | |||
| Atorvastatin | Product Listing: Bullets | Generic form of lipitor | https://www.everydayhealth.com/drugs/lipitor | ||||
| Atorvastatin | Product Listing: Bullets | Prevents plaque build-up in artery walls | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489607/ | ||||
| Atorvastatin | Product Listing: Bullets | Improves LDL, HDL & Triglyceride levels | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464917/ | ||||
| Atorvastatin | Product Listing: Bullets | May reduce risk of heart disease | https://link.springer.com/article/10.2165/00003495-200767001-00004 | ||||
| Atorvastatin | Product Details: Benefits Bullets | ||||||
| Atorvastatin | Product Details: Benefits Bullets | Generic form of Lipitor | |||||
| Atorvastatin | Product Details: Benefits Bullets | Effectively lowers “bad” cholesterol (LDL) in liver & blood | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464917/ | ||||
| Atorvastatin | Product Details: Benefits Bullets | Improves “good” cholesterol (HDL) | https://pubmed.ncbi.nlm.nih.gov/12125226/ | ||||
| Atorvastatin | Product Details: Benefits Bullets | Helps reduce risk for plaque build-up, heart attack & stroke | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489607/ | ||||
| Atorvastatin | Product Details: Benefits Bullets | May reduce risk for heart & cardiovascular disease | https://link.springer.com/article/10.2165/00003495-200767001-00004 | ||||
| Atorvastatin | Product Details: Benefits Bullets | Convenient once-daily dose | |||||
| Atorvastatin | Product Details: Key Benefits | ||||||
| Atorvastatin | Product Details: Key Benefits | LDL/HDL improvement | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464917/ | ||||
| Atorvastatin | Product Details: Key Benefits | Triglyceride improvement | https://www.ncbi.nlm.nih.gov/books/NBK395573/ | ||||
| Atorvastatin | Product Details: Key Benefits | Cholesterol improvement | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464917/#:~:text=Atorvastatin%20showed%20a%20consistent%20effect,about%20three%E2%80%90fold%20less%20potent. | ||||
| Atorvastatin | Product Details: Key Benefits | Overall Heart Health | https://link.springer.com/article/10.2165/00003495-200767001-00004 | ||||
| Atorvastatin | Background and History: Bullets | ||||||
| Atorvastatin | Background and History: Bullets | HMG-CoA reductase inhibitor originally synthesized in 1985 | |||||
| Atorvastatin | Background and History: Bullets | Later known as Lipitor in 1996, when it was FDA-approved | |||||
| Atorvastatin | Background and History: Bullets | Commonly prescribed to help improve cholesterol levels | |||||
| Atorvastatin | Background and History: Bullets | Used in combination with healthy diet & exercise | |||||
| Telmisartan | Product Listing: Bullets | ||||||
| Telmisartan | Product Listing: Bullets | Lowers Blood Pressure | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993985/#:~:text=Telmisartan%2Dbased%20treatment%20produced%20highly,p%3C0.0001%20for%20both). | ||||
| Telmisartan | Product Listing: Bullets | May reduce risk of heart disease | |||||
| Telmisartan | Product Details: Benefits Bullets | Generic form of Micardis | |||||
| Telmisartan | Product Details: Benefits Bullets | Telmisartan helps to lower high blood pressure to prevent strokes, heart attacks, and kidney problems. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993985/#:~:text=Telmisartan%2Dbased%20treatment%20produced%20highly,p%3C0.0001%20for%20both). | ||||
| Telmisartan | Product Details: Benefits Bullets | Telmisartan belongs to a class of drugs called angiotensin receptor blockers (ARBs). It works by relaxing blood vessels so blood can flow more easily | https://www.webmd.com/drugs/2/drug-16800/telmisartan-oral/details | ||||
| Telmisartan | Background and History: Bullets | ||||||
| Telmisartan | Background and History: Bullets | scale of hypertension in US | https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/217526#:~:text=Table%204%20presents%20a%20high,hypertension%20and%2027%25%20had%20hypertension | ||||
| Telmisartan | Background and History: Bullets | Lowers LDL | https://pubmed.ncbi.nlm.nih.gov/17533580/ | ||||
| Telmisartan | Background and History: Bullets | "Mildly" improves HDL cholesterol relative to Valsartan and Candesartan |
https://diabetesjournals.org/care/article/28/3/757/27733/Replacement-of-Valsartan-and-Candesartan-by | ||||
| Telmisartan | Background and History: Bullets | Reduces/protects against LVH | https://www.ahajournals.org/doi/full/10.1161/circulationaha.109.865774 | ||||
| Telmisartan | Background and History: Bullets | Protects your kidneys | https://pubmed.ncbi.nlm.nih.gov/15516696/ | ||||
| Telmisartan | Background and History: Bullets | Reduces your risk of developing dementia | https://pubmed.ncbi.nlm.nih.gov/24406780/ | ||||
| Telmisartan | Background and History: Bullets | Improves insulin resistance | https://journals.lww.com/americantherapeutics/Abstract/2018/12000/Telmisartan_Improves_Insulin_Resistance__A.5.aspx | ||||
| Telmisartan | Background and History: Bullets | Increases IGF-1 | https://pubmed.ncbi.nlm.nih.gov/19665690/ | ||||
| Telmisartan | Background and History: Bullets | Increases your endurance (at higher dosages) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823201/ | ||||
| Telmisartan | Background and History: Bullets | Taking at bedtime lowers diabetes risk | https://www.eurekalert.org/news-releases/569107 | ||||
| Telmisartan | Background and History: Bullets | Improves blood pressure | https://www.mayoclinic.org/drugs-supplements/telmisartan-oral-route/side-effects/drg-20067196?p=1#:~:text=Telmisartan%20is%20an%20angiotensin%20II,and%20oxygen%20to%20the%20heart. | ||||
| Acarbose | Product Listing: Bullets | Reduces post-mealtime glucose spikes | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620230/ | ||||
| Acarbose | Product Listing: Bullets | Blocks simple carbs to help maintain healthier weight | https://www.frontiersin.org/articles/10.3389/fendo.2020.00288/full | ||||
| Acarbose | Product Listing: Bullets | Helps maintain more stable blood sugar levels | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476372/ | ||||
| Acarbose | Product Details: Key Benefits | Slows digestion of carbs to help control blood sugar levels | https://www.drugs.com/mtm/acarbose.html&sa=D&source=docs&ust=1663615935011968&usg=AOvVaw2NQrywDZWTiIzJdVD7AMyG | ||||
| Acarbose | Product Details: Key Benefits | Helps prevent post-meal time glucose spikes | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620230/&sa=D&source=docs&ust=1663615935016443&usg=AOvVaw1BeqCOby8TRmN-imMQnj80 | ||||
| Acarbose | Product Details: Key Benefits | Reduces risk of cardiovascular events | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620230/&sa=D&source=docs&ust=1663615935017586&usg=AOvVaw3Cjjz_1_8lrtsuWhUeIBkt | ||||
| Acarbose | Background and History: Bullets | Most commonly used & studied alpha-glucosidase inhibitor | https://www.ncbi.nlm.nih.gov/books/NBK557848/&sa=D&source=docs&ust=1663615935020298&usg=AOvVaw2zd2kQr92oTzwb23-retcB | ||||
| Acarbose | Background and History: Bullets | Inhibits absorption of carbs from the small intestine to reduce blood sugar spikes | https://www.ncbi.nlm.nih.gov/books/NBK557848/&sa=D&source=docs&ust=1663615935021003&usg=AOvVaw19YCo37k7cfcEjyJzt_Sl- | ||||
| Acarbose | Background and History: Bullets | Helps to decreases glycemic index of carb-rich foods | https://pubmed.ncbi.nlm.nih.gov/12569112/&sa=D&source=docs&ust=1663615935020615&usg=AOvVaw3cIc4LLgAPsKW-gYhSLUh5 | ||||
| Acarbose | Background and History: Bullets | Lower glycemic indexes may help to prevent diabetes, heart disease & obesity | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620230/%23R10&sa=D&source=docs&ust=1663615935019902&usg=AOvVaw3NL834H0cEiKaoSpsn7Ji7 | ||||
| Acarbose | Background and History: Bullets | FDA approved to treat type 2 diabetes since 1999 | https://www.accessdata.fda.gov/drugsatfda_docs/nda/99/020482S010_Precose.cfm&sa=D&source=docs&ust=1663615935014603&usg=AOvVaw0m-i5aGxigIdJuYiZR6tOP | ||||
| LDN | Benefits | Better Moods, reduced pain, less fatigue | |||||
| LDN | Benefits | better mood | Increases endorphin levels up to 3x | ||||
| LDN | Benefits | reduced pain | Clinical evidence in reducing chronic pain | ||||
| LDN | Benefits | less fatigue | |||||
| LDN | Benefits | Modulates the immune system | Featured Article: Serum [Met 5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone | Methionine enkephalin (MENK) improves lymphocyte subpopulations in human peripheral blood of 50 cancer patients by inhibiting regulatory T cells (Tregs) | Immunomodulatory effects of endogenous and synthetic peptides activating opioid receptors | ||
| LDN | Benefits | Serum [Met5]-enkephalin levels were lower in humans with multiple sclerosis relative to non-multiple sclerosis patients, and low-dose naltrexone restored their levels. | All data obtained were of significance statistically. It was therefore concluded that MENK could work as a strong immune booster with great potential in restoring damaged human immune system and we could consider MENK as a drug to treat cancer patients, whose immune systems are damaged by chemotherapy or radiotherapy. | Much less is known about the immunomodulatory effects exerted by endogenous (enkephalins, endorphins, dynorphins and endomorphins) and synthetic peptides activating opioid receptors. In this review we tried to summarize opioid peptide-mediated modulation of immune cell functions which can be stimulatory as well as inhibitory | |||
| LDN | Benefits | Increases endorphin levels up to 3x | https://todayspractitioner.com/wp-content/uploads/2013/10/Bernard-Bihari-MD-Low-dose-Naltrexone-for-Normalizing-Immune-System-Function-athm_19_2_bihari_56_65.pdf | A pilot trial of low-dose naltrexone in primary progressive multiple sclerosis | Not supportive of increase - Interestingly, the endogenous opioid β-endorphin, often considered the “feel-good” peptide secreted during periods of exercise, was comparable in all non-MS and MS patients whether they were taking LDN or not. | ||
| LDN | Benefits | Lowers markers of inflammation in the body | Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia | Low-Dose Naltrexone Therapy Improves Active Crohn’s Disease | We found that LDN was associated with reduced plasma concentrations of interleukin (IL)-1β, IL-1Ra, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p40, IL-12p70, IL-15, IL-17A, IL-27, interferon (IFN)-α, transforming growth factor (TGF)-α, TGF-β, tumor necrosis factor (TNF)-α, and granulocyte-colony stimulating factor (G-CSF). | ||
| LDN | Benefits | We found that LDN was associated with reduced plasma concentrations of interleukin (IL)-1β, IL-1Ra, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p40, IL-12p70, IL-15, IL-17A, IL-27, interferon (IFN)-α, transforming growth factor (TGF)-α, TGF-β, tumor necrosis factor (TNF)-α, and granulocyte-colony stimulating factor (G-CSF). | C-reactive protein levels decreased from a median value of 2.6 (normal <0.8) at baseline to a value of 0.9 by the 12th week of treatment, and this change was statistically significant (P = 0.03). | ||||
| LDN | Benefits | Reduces fatigue & brain fog | Low Dose Naltrexone for Treatment of Multiple Sclerosis A Retrospective Chart Review of Safety and Tolerability | ||||
| LDN | Benefits | Nearly 60% (n = 128) of patients receiving LDN for any period of time reported a reduction in fatigue with LDN therapy. |
|||||
| LDN | Benefits | Clinical evidence in reducing chronic pain | Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study | Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels | 23 and me survey: What Patients Say Works for Fibromyalgia |
||
| LDN | Background and History | Prescribed for 40+ years with outstanding safety record | A pilot trial of low-dose naltrexone in primary progressive multiple sclerosis | ||||
| LDN | Background and History | Our data clearly indicate that LDN is safe and well tolerated in patients with PPMS | |||||
| LDN | Background and History | FDA approved to treat opiate dependencies & obesity | This is a fact | ||||
| LDN | Background and History | Dosages below 10mg/day are considered "Low Dose Naltrexone" (LDN)—4.5mg/day is the most common | This is a fact | ||||
| LDN | Background and History | Exhibits novel & paradoxical effects for a variety of conditions | Can this be claimed given support for the other claims? | ||||
| LDN | Background and History | Used to treat autoimmune diseases & viral infections since 1985 | This is a fact | ||||
| LDN | Background and History | Naltrexone has been prescribed for 40+ years with an outstanding safety record | This is a fact | ||||
| LDN | Background and History | Dosages below 10mg/day are considered "Low Dose Naltrexone" (LDN) - 4.5mg/day is the most common | This is a fact | ||||
| LDN | Background and History | At low doses, LDN is shown to reduce chronic inflammation, autoimmunity, and chronic pain | Need to change this wording | ||||
| LDN | Background and History | LDN lowers ESR (erythrocyte sedimentation rate), a marker of inflammation in the body | Low-Dose Naltrexone Therapy Improves Active Crohn’s Disease | ||||
| LDN | Benefits | Clinical evidence in reducing Fibromyalgia pain | See the following claim: | Clinical evidence in reducing chronic pain | |||
| LDN | Benefits | Lowers markers of inflammation in the body | See the following claim: | Lowers markers of inflammation in the body | |||
| LDN | Benefits | Normalizes immune system responses | See the following claim: | Modulates the immune system | |||
| LDN | Benefits | Effective, inexpensive, and highly tolerable | don't need support for this |